Priyanka Karki is a Nepalese film actress and the winner of the Miss Teen Nepal 2005 pageant.

Karki appeared in Bhulne Po Ho Ki, a small movie project in the USA. She later played a prostitute in Jholay, opposite Dayahang Rai. Jholay grossed over 10 million at the box office. Her next big release was Nai Nabannu La 2 opposite Suraj Singh Thakuri, which grossed over four million NPR. She also appeared in several music videos, including 'Guras Fulyo Banai Bhari' a song by Kishor Siwakoti and Asha Bhosle.

Karki's performances in Jholay and Nai Na Bhannu La 2 earned her the Online Filmykhabar Award as Best Actress 2017, NEFTA Award for Best Actor in a supporting role (Female), INFA award for Best Actor in a Supporting Role (Female) and INFA Most Popular Actor (Female).

Her next release Aawaran did not perform as well as previous movies at the box office. Although not a commercial success, it launched Karki as a singer in the Nepalese music industry, and she went on to sing the original soundtrack of Aawaran in collaboration with Yama Buddha.

Karki's Suntali was selected to premiere at the 19th Busan International Film Festival under the category 'A Window on Asian Cinema', on the fifth day of the festival. Suntali was released in February 2015 and although not a success commercially, Karki won Best Actor (Female) at the National Film Critics Award (NFCA) and the NFDC National Film Awards 2017.

In 2015, Karki starred as the title character in the horror/thriller film Mala, a widow, with long black hair and a white sari who is seen throughout the film but speaks only one word. At the NFDC National Film Awards 2017, the Jury award was conferred to director Sudip Singh Bhusal for Mala. Karki featured on the song "Surke Thaili Khai"; it went on to become the first Nepali song to reach 20 million views on YouTube.

In 2016, Karki appeared as 'Ani' in the fourth installment of the Nai NaBhannu La series. Nai NaBhannu La 4 grossed over 20 million in its first week of release. Soon after, Karki portrayed a female detective opposite Keki Adhikari in the comedy film How Funny.

At the end of the year, Karki was seen as a police inspector in the family drama Shatru Gatey. Her work was highly praised and the movie went on to become one of the most successful movies in Nepali film history celebrating 100 days at the theatre. Karki next appeared in the comedy/social drama Kohalpur Express alongside Keki Adhikari and Reecha Sharma. This female-centric film was highly successful at the box office, though receiving mixed reviews. Karki's releases for 2018 were Katha Kathmandu opposite Ayushman Deshraj Joshi, and Nai Na Bhannu La 5.

Karki recorded Bachchu Kailash's classic "Timi le ta Hoina" which is a cover song and released a video for it. Karki also collaborated with YouTube performer Nattu Shah and recorded a cover version of Jason Mraz and Colbie Caillat's 'Lucky'. Karki's debut single "Swatantra", which is about freedom, liberation, and independence, was released on January 1, 2016. The single had more than 300,000 views during the first two weeks and it hit a million views in the first two months.

Karki is one of the judges for the first international dancing reality show Boogie Woogie Nepal alongside choreographer Kabiraj Gahatraj and actor Dilip Rayamajhi.

Priyanka Karki married Rochak Mainali when she was 22; the couple divorced two years later. She appeared with Mainali on a show called Jeevan Sathi in 2012. She became engaged to Ayusman Deshraj Joshi in July 2018.The couple married on 27th February 2020.